In 2019, Chinese researchers revealed for the first time the mechanism of Panax ginseng extract to improve obesity by regulating intestinal flora, which is also the highest-level academic paper published in the field of ginseng research worldwide.
The gut microbiota is an important environmental factor for energy acquisition and storage in obese patients, and previous studies have proposed strategies to prevent and treat obesity by modulating the gut microbiota, such as the use of prebiotics and probiotics that can improve host metabolism and reduce obesity and related metabolic diseases.
Panax ginseng extract can treat obesity by regulating intestinal flora
Panax ginseng is widely used as traditional medicine or functional food. Ginsenosides, the main active components of Panax ginseng extract, have various biological functions, including anti-obesity and obesity-related diseases, and they can be metabolized to rare species through deglycosylation by gut microbiota before being absorbed into the bloodstream. In addition, studies have shown that long-term administration of Panax ginseng extract (GE) can alter the composition of the gut microbiota.
In conclusion, this study demonstrates that the Panax ginseng extract-E. faecalis-long-chain fatty acid axis combats obesity by increasing brown adipose tissue activity and beige adipogenesis by integrating data from gut microbiota, serum metabolites, and brown adipose tissue.