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Goji berry extract has the function of improving the skin barrier through Nrf2/HO-1 regulation

Updated: Jun 8, 2022

Goji berry is becoming more and more popular due to its strong biological activity and medicinal value. However, the effects of Goji berry extract on the skin are still unknown.

Goji berry

A new study uses the LC-HRMS/QTOF method to investigate phenolic compounds in Goji berry extract and to investigate whether topical application of Goji berry extract can repair skin barrier dysfunction in mice.

The data showed that Goji berry extract not only reduced ROS levels and expression of matrix metalloproteinases but also enhanced enzymes including superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and catalase ( CAT), thereby increasing the collagen content of the skin and improving UV-induced skin thickening, erythema, and wrinkles.

Improvements in skin barrier function were highly correlated with increased expression of filaggrin, involucrin, and loricrin, and antioxidant proteins such as Nrf2 and HO-1 in UV-irradiated mice. This suggests that Goji berry extract holds promise as a low-cost natural product for topical treatment of skin diseases caused by defective barrier function.



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