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New study published: Why are women more susceptible to Alzheimer's disease?

Updated: Mar 6, 2022

On March 3rd, Beijing time, the latest issue of the world's top journal, "Nature", was published online. Deputy Chief Physician Xiong Jing, Department of Neurology, People's Hospital of Wuhan University, is the first author of the research paper "The effect of inhibiting follicle-stimulating hormone can be Improve Alzheimer's disease in mice

Cognitive Dysfunction", the research results revealed for the first time in the world that follicle-stimulating hormone is the reason why elderly women are more susceptible to Alzheimer's disease, and provides a new program for early screening and intervention of the disease.

According to Xiong Jing, Alzheimer's disease (AD) is an age-dependent neurodegenerative disease and the most common cause of dementia in the elderly. The main clinical manifestations are memory dysfunction, abnormal behavior and decreased ability of daily living. One person is diagnosed with Alzheimer's disease every 3 seconds in the world, and there are currently more than 50 million people with Alzheimer's disease in the world. With the advent of an aging society, this number is expected to increase substantially to 152 million by 2050. Epidemiological surveys have shown that the number of women with Alzheimer's disease in the elderly is about twice as high as that of men, but the cause of this phenomenon has remained unclear.

Based on this theory, Xiong Jing and other research teams have studied hormones whose concentrations vary sharply in women before and after menopause, and tested which hormones can selectively activate the C/EBPβ-AEP pathway. This newly published paper reveals for the first time that elevated follicle-stimulating hormone (FSH) is an important reason why older women are more prone to Alzheimer's disease than men: women's levels of follicle-stimulating hormone in the body rise sharply during perimenopause To more than 10 times, and the follicle-stimulating hormone level in older men is about 3 times higher than that in young men. The sharply elevated FSH in premenopausal women aggravates Aβ and Tau lesions in the brain of Alzheimer's disease patients by activating the C/EBPβ-AEP signaling pathway, resulting in memory impairment. This important discovery not only provides a new reason and new mechanism for why women are more prone to AD, but also provides a new target for early clinical screening and intervention of Alzheimer's disease.



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