Codonopsis pilosula is the dry root of Codonopsis and Sichuan Codonopsis. The phytochemical composition of Codonopsis is complex. At present, scholars at home and abroad have isolated and identified more than 230 compounds from Codonopsis plants, including alkaloids, alkynes, terpenes, flavonoids, lignins, steroids, sugars, and other components. Among them, alkaloids, polyalkynes, lignans, flavonoids, and polysaccharides are considered to be the main active ingredients. Codonopsis pilosula has a variety of pharmacological effects, mainly in the nervous system, endocrine system, immune system, etc.
1. Protection of the nervous system
Codonopsis pilosula extract has neuroprotective effects such as protecting nerve cells, improving learning and memory ability, and reducing symptoms of Alzheimer's disease (AD). Codonopsis pilosula aqueous extract and monomer component Lancemaside A can up-regulate the activity of protein phosphatase 2 (PP2A), reduce the phosphorylation level of Tau protein, repair damaged neurons, and inhibit the activity of AChE.
2. Regulate blood sugar and blood lipids
Codonopsis pilosula extract has the effect of regulating blood sugar and blood lipids. Codonopsis pilosula water extract can lower blood sugar, inhibit aldose reductase activity, and delay the progression of diabetes.
3. Effects on the immune system
Codonopsis pilosula can regulate the immune balance of the body. Codonopsis methanol extract can modulate macrophage-mediated immune responses and promote anti-inflammatory activity.
4. The effect on the digestive system
Codonopsis pilosula extract has pharmacological effects such as treating gastric ulcers, promoting intestinal promotion, and improving the body's digestive ability.
5. The effect on blood circulation
Codonopsis pilosula extract has the functions of treating heart failure, regulating blood cell growth and development, enhancing hematopoietic function, and inhibiting platelet aggregation.