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What are the physiological roles of GABA in improving sleep?

γ-aminobutyric acid, also known as GABA, is an amino acid that exists in the human brain and is an important inhibitory neurotransmitter in the nervous system. Appropriate supplementation of GABA can better relieve mental stress, regulate emotions, and improve sleep.


GABA is the primary neurotransmitter that initiates sleep mechanisms. When the human body needs to rest, the brain releases the neurotransmitter GABA, which reduces nerve excitability and relaxes the nerves. The study found that the level of GABA in brain tissue increased by 15% in sleep compared with wakefulness.


The physiological effects of GABA in improving sleep are mainly:


Relieve anxiety and inhibit excitation: GABA acts as a major inhibitory neurotransmitter in the central nervous system and participates in cerebral circulation physiological activities. Appropriate supplementation of GABA can relieve anxiety and inhibit excitement, thereby improving sleep;


Promote metabolism: GABA can increase the activity of hexokinase in the tricarboxylic acid cycle (TCA), thereby accelerating the metabolism of glucose in the brain, ultimately increasing the blood supply and oxygen supply to the brain, and promoting sleep.

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